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If you’ve been researching weight loss medications during menopause, you’ve likely come across two names: Wegovy vs Mounjaro. Both are highly effective GLP-1 weight loss medications, but they work slightly differently. Here’s what you need to know to make an informed decision about these weight loss injections.
The Key Difference Between Mounjaro vs Wegovy
Wegovy (Semaglutide):
- Single-action GLP-1 receptor agonist
- Weekly injection
- Prescribed specifically for weight loss
- Proven to help patients lose 14.9-15.2% of body weight in clinical trials
Mounjaro (Tirzepatide):
- Dual-action GLP-1 and GIP receptor agonist
- Weekly injection
- Prescribed for both diabetes and weight loss
- The dual hormone action may offer enhanced benefits for blood sugar and weight regulation
How These Weight Loss Medications Work
Both Wegovy and Mounjaro:
- Slow gastric emptying (you feel fuller for longer)
- Reduce appetite and cravings
- Help regulate blood sugar levels
- Support significant weight loss when combined with lifestyle changes
The advantage of Mounjaro’s dual action is that it targets two hormone pathways instead of one, potentially offering more comprehensive metabolic benefits for weight loss.
Mounjaro vs Wegovy Effectiveness for Weight Loss
Clinical studies show both GLP-1 medications are highly effective:
- Wegovy: 14.9-15.2% body weight loss over 68-104 weeks
- Mounjaro: Studies suggest potentially greater weight loss due to dual hormone action, though individual results vary
Weight Loss Injections and Menopause: Important Considerations
HRT Interaction Alert: If you’re taking oral HRT (particularly oral progesterone), Mounjaro may affect absorption due to slowed gastric emptying. Always discuss this with your prescribing doctor – they may recommend alternative HRT forms or adjust dosages.
Wegovy vs Mounjaro Side Effects
Both weight loss medications can cause:
- Nausea (most common initially)
- Gastrointestinal upset
- Reduced appetite
- Potential muscle loss with rapid weight loss (why protein intake and resistance exercise are crucial)
Can I Get Mounjaro on NHS? Access to Weight Loss Medications UK
Both require prescription and are only suitable for those meeting specific criteria:
- BMI ≥35 with weight-related health conditions, OR
- BMI ≥32.5 (or lower thresholds for certain ethnic groups)
- Must be combined with lifestyle changes
- Available privately or through NHS (limited availability)
Which is Better Wegovy or Mounjaro for Weight Loss?
Both Wegovy and Mounjaro are effective tools for weight management during menopause. The choice between them often depends on:
- Your individual health profile
- Whether you have diabetes
- How you respond to treatment
- Your doctor’s clinical assessment
Remember: These aren’t quick fixes. Success requires commitment to sustainable lifestyle changes alongside weight loss medication.
Want to Learn More About GLP-1 Weight Loss Medications?
For a comprehensive guide covering everything about GLP-1 medications for weight loss, including safety considerations, dietary advice, and who they’re suitable for, I highly recommend reading this excellent post by Registered Nutritionist Lucy Jones: GLP-1 Medications for Weight Loss at Menopause
Weight Loss Medication Consultation Milton Keynes
Ready to explore your options? At The Female Health Doctor, we provide doctor-led weight loss consultations with Mounjaro, reviewing your symptoms, weight, and health profile to determine if it’s right for you.
Our weight loss clinic in Milton Keynes offers both virtual and in-person appointments, making it convenient for busy professional women to access expert care.
